Top 3 Skin Concerns Rejuran Microneedling Treats
Rejuran microneedling is a skin treatment designed to tackle three common concerns: fine lines, uneven skin tone, and enlarged pores. By combining microneedling with polynucleotides (PNs) derived from salmon DNA, this procedure stimulates collagen production and promotes skin repair. It’s a non-surgical option with minimal downtime, making it a popular choice for early signs of aging and surface-level texture issues.
Key Benefits:
Fine Lines and Wrinkles: Reduces early signs of aging by boosting collagen and elastin production.
Uneven Tone and Dullness: Improves skin brightness, hydration, and mild pigmentation issues.
Enlarged Pores and Texture: Smooths rough skin and minimizes pore size by strengthening structural support.
What to Expect:
Results appear gradually over 6–12 weeks with a series of 3–6 sessions spaced 3–4 weeks apart.
Minimal downtime: mild redness or swelling resolves in 1–3 days.
Suitable for most skin types but not recommended for active acne, open wounds, or certain medical conditions.
Rejuran microneedling works best when combined with a tailored skincare plan, including sunscreen and gentle products. It’s ideal for those seeking natural-looking improvements without opting for more aggressive treatments.
How Rejuran Microneedling Works
Rejuran microneedling combines advanced techniques with unique ingredients to rejuvenate the skin. Using ultra-fine needles, this treatment creates tiny, controlled micro-injuries in the skin. These micro-injuries stimulate the production of collagen and elastin, key components for firm and youthful skin. At the same time, the procedure forms microchannels that enhance the absorption of serums applied during the treatment.
The star ingredient in Rejuran is polynucleotides derived from salmon DNA. Once these polynucleotides reach the dermis, they work at a cellular level to activate dermal fibroblasts through cellular signaling. This process boosts collagen production, remodels the skin’s structure, and increases hyaluronic acid levels. The result? Skin that’s better hydrated, more elastic, and smoother in texture. Additionally, its anti-inflammatory properties help calm irritation and support the skin’s barrier, making it a gentle option even for those with sensitive or reactive skin.
What Happens During Treatment
A typical Rejuran microneedling session lasts between 30 and 60 minutes. The treatment begins with a thorough cleansing of the skin, followed by the application of a topical numbing cream to minimize discomfort. The provider then uses a microneedling device – such as a derma roller or an automated pen – to create the microchannels. Immediately after, the Rejuran serum is applied to maximize absorption through these channels. Most patients describe the sensation as mild, often likened to light scratching.
Recovery and Post-Treatment Care
One of the appealing aspects of Rejuran microneedling is its minimal downtime. After the procedure, you might notice mild redness, swelling, or a sensation similar to a sunburn. These effects usually subside within 24 to 72 hours. In some cases, minor bleeding or flaking may occur as the skin heals.
Post-treatment care is straightforward. Avoid direct sunlight, strenuous exercise, and harsh skincare products for a few days. Instead, focus on gentle cleansing, regular moisturizing, and applying a broad-spectrum SPF 30 or higher daily to protect the healing skin and maintain your results.
Who Benefits Most and Who Should Avoid It
Rejuran microneedling works well for a variety of skin types, including sensitive or reactive skin. It’s particularly helpful for addressing early signs of aging, such as fine lines, uneven skin tone, mild hyperpigmentation, enlarged pores, and rough texture.
However, it’s not suitable for everyone. Those with active acne, severely compromised skin barriers (like open wounds or severe eczema), bleeding disorders, a history of keloid scarring, active skin infections (such as cold sores), or individuals on medications like isotretinoin that increase skin sensitivity should avoid this treatment.
Treatment Series and Timeline
For the best results, a series of 3–6 sessions spaced 3–4 weeks apart is recommended. This schedule gives the skin time to remodel collagen and recover between treatments. Many patients notice improvements in skin texture, brightness, and hydration within one to two weeks after their first session. More noticeable changes, such as reduced fine lines and minimized pores, typically appear after 2–3 sessions. Since Rejuran promotes ongoing collagen remodeling, improvements often continue for weeks after each treatment. Maintenance sessions every 6–12 months may be suggested to preserve results.
A 2022 randomized split-face clinical trial supports the effectiveness of Rejuran. The study found that polynucleotide-based treatments significantly improved skin roughness and pore volume compared to mesotherapy with hyaluronic acid, providing clinical evidence for its benefits [1].
1. Fine Lines and Early Wrinkles
Fine lines and early wrinkles often show up first around the eyes, forehead, and mouth, signaling the initial stages of aging. Rejuran microneedling targets these issues by tapping into your skin’s natural ability to heal and renew itself at the cellular level.
How It Addresses Specific Skin Concerns
Rejuran microneedling has shown great promise for early signs of aging, particularly for fine lines caused by sun exposure and other superficial factors. A 2022 randomized split-face study highlighted its effectiveness, showing noticeable improvements in skin texture and smoothness with polynucleotide-based treatments [1]. This method not only reduces fine lines but also enhances the skin’s overall appearance, leaving it with a more even, radiant glow.
How It Works
The treatment combines controlled micro-injuries with the delivery of polynucleotides to supercharge collagen and elastin production. These polynucleotides activate fibroblasts, which help remodel the extracellular matrix, increase natural hyaluronic acid levels, and strengthen the skin barrier. Additionally, this process improves hydration while reducing inflammation and oxidative stress – two major culprits behind premature aging [1][2].
What to Expect
Reducing fine lines with Rejuran microneedling isn’t an overnight fix. Improvements build gradually over several sessions, with visible results typically appearing within a few weeks. The most noticeable collagen production and skin enhancement occur between 6 and 12 weeks [3]. This steady improvement sets the stage for broader skin rejuvenation efforts.
Combining with Other Treatments
Rejuran microneedling pairs well with other skin treatments, making it a flexible option in comprehensive skincare plans. It can be used as a follow-up to injectable treatments or laser procedures, enhancing collagen production and supporting overall skin repair. This adaptability allows for personalized strategies to tackle specific skin concerns while promoting long-term rejuvenation.
2. Uneven Tone, Dullness, and Mild Hyperpigmentation
Struggling with dull, uneven skin tone? These common concerns often stem from factors like sun exposure, inflammation, and the natural decline in cell turnover that comes with aging. Rejuran microneedling works at the cellular level to tackle these issues, leaving your skin looking brighter, smoother, and more refreshed.
How It Addresses Specific Skin Concerns
Rejuran microneedling is particularly effective for dealing with superficial skin concerns like uneven tone, lack of radiance, and mild discoloration caused by sun damage. By boosting hydration and enhancing skin luminosity, it helps to improve early signs of photoaging and smooth out pigment irregularities. The polynucleotides in the treatment play a key role by accelerating cell turnover and aiding DNA repair, which can fade sun spots, lighten mild melasma, and calm redness or post-inflammatory marks. Clinical studies back its effectiveness [1].
For those with darker skin tones, this treatment is a safer alternative to lasers, which may carry higher risks. Rejuran microneedling’s focus on cellular rejuvenation not only brightens the skin but also addresses uneven tone and pigmentation without compromising safety.
How It Works
The treatment uses microchannels to deliver polynucleotides deep into the skin. These compounds promote cell turnover, balance pigmentation, and improve skin texture, all while enhancing the skin’s overall health.
What to Expect from the Results
Results develop gradually over a series of three to four sessions. Over six to twelve weeks, you’ll notice improvements in skin hydration, more even pigmentation, and increased collagen production. With minimal downtime – most people experience mild redness or swelling for just one to three days – this treatment is easy to fit into a busy lifestyle. To maintain and enhance results, using a broad-spectrum sunscreen and pigment-safe skincare between sessions is essential [3].
Pairing with Other Treatments
Rejuran microneedling works even better when combined with other treatments. Pairing it with chemical peels or laser procedures can amplify its brightening effects. By strengthening the skin’s barrier and boosting moisture retention, this treatment helps maintain a radiant, even-toned complexion in the long run.
3. Enlarged Pores and Rough Texture
Enlarged pores and rough skin texture can significantly impact the appearance of your complexion, often giving it an uneven and aged look. These issues commonly arise when collagen support around the pores weakens, causing them to stretch and become more noticeable. Factors like sun exposure, aging, and past acne can further contribute to a bumpy and uneven skin surface. Rejuran microneedling addresses these concerns by rebuilding the skin’s structural support, helping to smooth out irregularities.
Effectiveness for Targeted Skin Concerns
Rejuran microneedling is particularly well-suited for individuals dealing with visible pores and uneven texture. The microneedling process creates controlled micro-injuries in the skin, which not only help break up surface irregularities but also stimulate collagen production. This leads to a smoother and more refined skin surface. It’s also a great option for those with sensitive or reactive skin who might struggle with more aggressive treatments. For patients seeking subtle, natural-looking improvements without injectables, this treatment offers an appealing alternative.
Mechanism of Action
Rejuran microneedling delivers results through a two-step process. First, the Rejuran serum, which contains polynucleotides, activates dermal fibroblasts. This strengthens the skin’s structure around the pores, improving firmness and elasticity. Second, the microneedling procedure creates tiny microchannels in the skin, enhancing the absorption of the serum into the epidermis and superficial dermis. This process promotes cell turnover, encourages the regeneration of healthier skin cells, and boosts hydration – all of which contribute to a smoother texture and less visible pores.
At Calista Aesthetics, the treatment begins with a detailed consultation and skin assessment. The procedure typically involves cleansing, applying a topical numbing agent, and microneedling at customized depths to target areas with prominent pores or rough texture, such as the T-zone and cheeks. The Rejuran serum is then infused through the microchannels. Each session lasts about 30–60 minutes, depending on the treatment area.
Realistic Expectations and Outcomes
Patients often see an improvement in skin smoothness and radiance within a few weeks as early collagen remodeling begins. More noticeable changes in pore size and texture develop gradually over a series of sessions, usually spaced 3–4 weeks apart. Significant results often emerge after 6–12 weeks, as new collagen forms and strengthens the skin. To maintain these benefits, multiple sessions and ongoing care are typically recommended.
The downtime is minimal, with mild redness, swelling, or pinpoint bruising resolving within 1–3 days. Post-treatment care includes using gentle cleansers, non-comedogenic moisturizers, and broad-spectrum sunscreen to protect the skin and prevent UV-induced collagen breakdown. Patients are also advised to avoid makeup, exfoliating acids, and retinoids for a few days to ensure optimal recovery.
Synergy with Complementary Treatments
While Rejuran microneedling can deliver impressive results on its own, combining it with other treatments can amplify the benefits. Pairing it with options like chemical peels, medical-grade skincare, or additional collagen-stimulating therapies can further refine texture, reduce pore size, and address other concerns like pigmentation and oil control. At Calista Aesthetics, Rejuran microneedling often forms part of a personalized treatment plan, which may include dermal fillers, neurotoxins, and customized home care, all designed to achieve balanced and natural-looking improvements.
Treatment Experience at Calista Aesthetics
At Calista Aesthetics, the Rejuran microneedling process is carefully designed to meet your unique skin needs and aesthetic goals through three key steps: consultation, treatment, and follow-up.
Initial Consultation and Skin Assessment
Your journey starts with a detailed consultation where you can discuss your specific concerns, whether it’s fine lines, uneven skin tone, large pores, or overall texture. A licensed provider will review your medical history, current medications, previous cosmetic treatments, and expectations to ensure your needs are fully understood.
The next step is a thorough skin evaluation. This includes assessing your skin type (using the Fitzpatrick scale), thickness, sensitivity, pore size, pigmentation patterns, and any active issues like acne or dermatitis. Standardized photos are often taken under consistent lighting to establish a baseline and help manage expectations, as collagen remodeling typically takes 6–12 weeks.
During this consultation, you’ll also explore how Rejuran microneedling fits into your broader aesthetic goals. For example, if deeper wrinkles or volume loss are concerns, your provider may suggest combining microneedling with other treatments like neurotoxins (e.g., Jeuveau or Dysport), dermal fillers, or chemical peels for a more comprehensive approach. This thorough evaluation sets the stage for a treatment plan tailored specifically to you.
The Treatment Session
Once you’re ready to proceed, the treatment session usually takes about 45–60 minutes, depending on the areas being addressed. The process begins with a thorough cleansing of your skin, followed by the application of a topical anesthetic, which is left on for 20–30 minutes to ensure comfort.
With your skin numbed, the microneedling begins. Using a sterile, single-use needle cartridge, the provider adjusts the needle depth to suit each area. For instance, delicate areas like under the eyes are treated with shallower passes, while areas with larger pores or uneven texture, such as the cheeks and T-zone, may require deeper treatment to stimulate collagen more effectively.
As the microneedling device creates controlled microchannels in your skin, a Rejuran polynucleotide serum is applied. This allows the serum to penetrate deeply, with extra attention given to areas of concern to maximize its regenerative effects. After the session, you’ll receive personalized instructions for post-treatment care.
Immediate Post-Treatment and Downtime
After the session, you may notice some redness and swelling as your skin begins the collagen repair process. Downtime is minimal compared to more invasive procedures, and most people see redness subside within 24–72 hours.
You’ll be provided with clear aftercare guidelines. For the first 24 hours, it’s important to avoid makeup, strenuous exercise, saunas, swimming, and direct sun exposure. Stick to a gentle, fragrance-free cleanser and a lightweight, non-comedogenic moisturizer to keep your skin hydrated and support its healing. Avoid active skincare ingredients until your skin has fully calmed. Once the recovery phase is over, daily application of a broad-spectrum sunscreen with SPF 30 or higher is crucial to protect your skin from UV damage.
Integrating Rejuran Microneedling into Your Personalized Plan
Rejuran microneedling at Calista Aesthetics is typically done as a series of 3–4 sessions, spaced about 3–4 weeks apart. This schedule helps build collagen and elastin over time, enhancing your skin’s overall quality. Between sessions, you’ll follow a customized home care routine focusing on gentle cleansing, barrier-supporting moisturizers, and daily sunscreen use to maintain and extend the results.
Every aspect of the treatment is tailored to your specific needs, ensuring natural-looking improvements and ongoing support throughout your journey.
Monitoring Progress and Adjusting Your Plan
Throughout your treatment series, progress is closely monitored using before-and-after photos and, when available, advanced skin analysis tools. These comparisons help track changes in pore size, pigmentation, and skin texture. While early benefits like improved hydration and smoother skin may appear within weeks, more noticeable results – such as firmer skin and softened fine lines – develop gradually over 6–12 weeks with consistent sessions.
Your feedback is also a key part of the process. Observations like how your makeup applies or how smooth your skin feels are considered when deciding if maintenance treatments should be part of your long-term plan. The team at Calista Aesthetics remains available to guide and support you every step of the way, ensuring your rejuvenation journey is as seamless and effective as possible.
Conclusion
Rejuran microneedling combines controlled micro-injuries with salmon-derived polynucleotides to address fine lines, uneven skin tone, and enlarged pores. Instead of offering quick, temporary fixes, this treatment works by stimulating collagen and elastin production, encouraging cell turnover for more balanced melanin distribution, and tightening collagen around pores to reshape the skin’s structure over time.
Patients often notice gradual yet visible improvements after their sessions. A brighter, more radiant complexion and smoother makeup application are common early benefits. Over time, fine lines around the eyes and mouth appear softened, sun damage and post-acne marks look more even, and pores become less noticeable as the skin continues to remodel.
Customizing the treatment to each individual is crucial for achieving the best results. At Calista Aesthetics, skilled professionals evaluate whether your skin concerns – such as fine lines, uneven tone, or enlarged pores – are linked to early photoaging, lifestyle habits, or other factors. During a detailed consultation, they’ll determine if Rejuran microneedling is the right choice for you or if it should be part of a broader skincare plan for balanced, natural-looking outcomes.
This treatment is ideal for adults noticing early signs of aging who prefer a non-surgical option with minimal downtime. Many patients in the United States schedule their sessions around work and social commitments. Starting treatments during cooler months or less sunny periods can make it easier to follow post-treatment sun protection guidelines. Your provider can also help plan sessions around vacations or major events to ensure the best results.
If you’re dealing with early crow’s feet, stubborn sunspots, or visible pores in your T-zone, consider scheduling a consultation at Calista Aesthetics. Bring along your skincare products and medical history so the team can design a personalized treatment and maintenance plan tailored to your lifestyle, budget, and comfort level. Discover naturally rejuvenated skin with a plan designed just for you at Calista Aesthetics.
FAQs
Rejuran microneedling takes microneedling to the next level by integrating polynucleotides – natural DNA fragments known to enhance skin regeneration, speed up healing, and encourage collagen production. This added component makes it especially effective for focused rejuvenation and promoting healthier skin over time.
Traditional microneedling, on the other hand, works by creating tiny, controlled injuries in the skin to kickstart collagen production. While both methods aim to improve skin texture and overall appearance, Rejuran microneedling goes a step further, offering added benefits like faster healing and deeper rejuvenation. It’s particularly well-suited for tackling fine lines, uneven skin tone, and enlarged pores.
Rejuran microneedling is considered safe and works well for most skin types. However, it’s not suitable for everyone. If you have active skin infections, severe acne, or open wounds, it’s important to wait until your skin has fully healed before considering this treatment. Additionally, individuals with a history of keloid scarring or heightened skin sensitivities should consult a professional to ensure it’s a good fit.
Not sure if Rejuran microneedling is the right choice for you? Booking a consultation with an expert provider, like the specialists at Calista Aesthetics, can help. They’ll evaluate your skin, discuss your concerns, and create a treatment plan designed just for you.
To keep your skin looking its best after Rejuran microneedling, focus on a skincare routine that prioritizes gentle care and hydration. Make broad-spectrum sunscreen your daily must-have – it helps shield your skin from harmful UV rays and reduces the risk of premature aging. Adding antioxidants like vitamin C to your routine can also boost skin repair and give your complexion a healthy glow.
Hydration is key, so choose a moisturizer that matches your skin type to maintain a strong skin barrier and lock in moisture. For ongoing results, think about scheduling follow-up treatments or consulting with a skincare expert. They can help fine-tune your routine and keep your skin looking vibrant and healthy.