Ultimate Guide to Microneedling with PRP

Close-up portrait of a woman with glowing skin touching her face, wearing a silk robe in a softly lit bathroom, beauty and skincare concept

Microneedling with PRP (Platelet-Rich Plasma) is a non-surgical skin treatment designed to improve acne scars, wrinkles, and uneven texture by combining microneedling with your blood’s natural growth factors. Here’s what you need to know:

  • How It Works: Microneedling creates tiny skin injuries to stimulate collagen production. PRP, extracted from your blood, enhances healing and boosts results.

  • Benefits: Smoother skin texture, reduced acne scars, fewer wrinkles, and quicker recovery compared to microneedling alone.

  • Safety: Suitable for all skin types with minimal risks, as PRP comes from your own blood.

  • Recovery: Mild redness and swelling subside in 1–3 days, with noticeable results in 2–3 weeks and continued improvement over months.

  • Cost: A full treatment plan ranges from $2,250 to $4,500, with individual sessions averaging $750.

This procedure is safe, effective, and backed by clinical research. For best results, choose a qualified provider using FDA-cleared devices like the SkinPen.

MICRO NEEDLING WITH PRP (Plasma Rich Protein)

Benefits of Microneedling with PRP

Microneedling with PRP offers a way to achieve noticeable skin improvements without the need for surgery or lengthy recovery. By tapping into your body’s natural healing processes, this treatment encourages lasting changes that enhance skin health and appearance. Let’s dive into some of the standout benefits.

Improves Skin Texture and Tone

This treatment works wonders for improving skin texture and tone through a process called dermal remodeling. Microneedling creates tiny channels in the skin, breaking up fibrous scar tissue and reducing the look of enlarged pores. At the same time, PRP (platelet-rich plasma) introduces growth factors into these channels, speeding up cell turnover and renewal [1][3]. The result? A smoother, more refined skin surface.

The benefits don’t stop there. The healing process triggered by the treatment stimulates collagen and elastin production, which continues long after the session. This ongoing improvement helps reduce scars and wrinkles naturally over time [4].

Reduces Acne Scars and Wrinkles

Microneedling with PRP is particularly effective for tackling acne scars and wrinkles. The microneedling component physically breaks down old scar tissue, encouraging the growth of new, healthy skin cells [6][8]. In one clinical study, participants with acne scars saw a 62.20% improvement when treated with microneedling and PRP, compared to 45.84% for those treated with microneedling and distilled water [1].

The PRP enhances this process by delivering growth factors deep into the skin, boosting tissue repair and encouraging collagen production. This not only helps smooth out fine lines but also restores youthful contours to the skin. Another study involving 113 patients found that improvements in skin smoothness and firmness lasted for up to 12 months after treatment [8].

Promotes Natural Healing and Collagen Production

One of the standout features of PRP is its ability to speed up recovery. Packed with cytokines and proteins, PRP reduces post-treatment inflammation and redness, meaning most patients experience only mild redness – similar to a light sunburn – for 1 to 3 days. This is a much shorter recovery time compared to the 4 to 7 days typically seen with microneedling alone [1][6].

“The growth factors in your PRP are far more powerful for healing and tissue regeneration than most topical treatments. This synergy leads to faster healing, superior collagen stimulation, and more noticeable, longer-lasting improvements.” – Scott Melamed, President and CEO, ProMD Health [6]

Another key benefit is the stimulation of collagen. PRP activates fibroblasts, the cells responsible for producing collagen and elastin – two proteins essential for skin elasticity and firmness. Since collagen production naturally declines by 1% to 2% each year starting in your twenties, this treatment helps counteract that loss, supporting healthier, more youthful skin over the long term [4].

What to Expect During and After Treatment

The Treatment Process

Microneedling with PRP is a simple and efficient procedure. It starts with cleansing your skin and applying a topical numbing cream for about 20–30 minutes to keep you comfortable. Meanwhile, a small sample of your blood is drawn and processed in a centrifuge to extract the PRP. Once your skin is numb, a device like the FDA-cleared SkinPen is used to create tiny micro-channels in your skin, a process that takes about 15–30 minutes. Right after, the PRP is applied to your skin, taking advantage of the freshly created micro-channels to boost its effectiveness. Afterward, your skin begins its recovery, showing temporary but visible changes.

Recovery After Treatment

Post-treatment, you can expect some redness, tightness, minor swelling, warmth, and pinpoint bleeding for about 24–72 hours. By days three to five, your skin might feel dry and start flaking as part of its natural exfoliation process. The good news? Downtime is minimal, and most of these effects clear up within a week.

To promote healing, avoid washing the treated area for 4–6 hours, skip skincare products with active ingredients for 5–7 days, and steer clear of intense exercise, saunas, and hot showers for 72 hours. Starting 24 hours after the procedure, use a mineral-based sunscreen with SPF 30+ daily and stay out of direct sunlight for at least a week.

When to Expect Results

You’ll start noticing improvements in your skin’s texture and brightness within 2–3 weeks. More substantial changes, like increased collagen production, typically appear in 4–6 weeks. For issues like acne scars, progress can continue for up to nine months [1]. Most people need a series of three to six sessions, spaced about four weeks apart, to achieve the best results [2][10]. After completing the initial treatments, maintenance sessions every six to 12 months can help preserve your results.

Interestingly, the fibronectin matrix, which plays a key role in collagen formation, begins developing around five days after treatment. The collagen type III produced during the healing process can remain in the skin for five to seven years [9]. These ongoing changes contribute to the lasting benefits of this treatment.

Safety, Side Effects, and Suitability

Is Microneedling with PRP Safe?

Microneedling with PRP is considered highly safe. Since PRP is derived from your own blood, the risks of allergic reactions, cross-contamination, or immune rejection are nearly nonexistent [1][5][7]. Unlike laser treatments that rely on heat, this technique avoids heat-related skin damage and does not affect pigmentation. Both the American Academy of Dermatology and the Mayo Clinic affirm that microneedling is safe for all skin tones and types [1][7]. This makes it a great option for individuals with darker Fitzpatrick skin types, who may face pigmentation challenges with other treatments.

Adding PRP to the procedure can further enhance safety by speeding up recovery and minimizing redness and swelling after the treatment [2][5]. Let’s take a closer look at the potential side effects.

Common Side Effects

Post-treatment, you might experience side effects similar to a mild sunburn. Redness and swelling are the most frequent reactions, typically appearing right after the procedure and improving within 48 hours. Most people see these effects fully subside in two to five days [8][2][1][11]. Other possible reactions include mild bruising, skin tightness, and sensitivity. Clinical studies show that redness occurs in 83.7% of patients using pen-type microneedling devices [12].

Less common issues include infections, small white bumps (milia), acne flare-ups, or cold sore outbreaks, especially if you have a history of herpes simplex [1][2][12]. Despite these possibilities, most individuals can return to their usual activities within 24 hours [8][7]. Knowing these potential side effects helps you make an informed decision about the treatment.

Who is a Good Candidate?

Microneedling with PRP is a great choice for those aiming to rejuvenate their skin, as long as they meet certain health requirements. It’s effective for treating acne scars, fine lines, wrinkles, large pores, uneven skin texture, stretch marks, and sun damage [1][5][4][7]. And better yet, it’s safe for all skin types and tones, including darker ones [1][11].

However, this procedure isn’t suitable for everyone. It’s not recommended for individuals who are pregnant or breastfeeding, have active acne or skin infections, or have used Accutane in the past six months. Additionally, those with blood disorders, cancers, or conditions like HIV/AIDS or Hepatitis C should avoid this treatment [1][2][7]. Other exclusions include recent radiation therapy (within 12 months), a history of keloid scarring, or heavy nicotine and alcohol use, which can hinder the healing process [11].

Here’s a quick overview of who qualifies and who doesn’t:

Category

Details

Ideal Candidates

Those with acne scars, fine lines, wrinkles, large pores, uneven skin texture, stretch marks, or sun damage [1][5]

Skin Type Suitability

Safe for all skin tones, including darker Fitzpatrick types [1][11]

Medical Contraindications

Pregnancy, breastfeeding, active acne or infections, HIV/AIDS, Hepatitis C, or skin cancer in the treatment area [1][2][7]

Recent History Risks

Accutane use or major surgery within 6 months, or radiation therapy within 12 months [1][2][7]

Blood/Systemic Issues

Blood disorders, low fibrinogen levels, anemia, or a history of keloid scarring [1][2][11]

Choosing the Right Provider

Once you’re familiar with the benefits and safety of microneedling with PRP, the next step is finding an experienced provider to ensure the best possible results.

Why Expertise Matters

The skill of your provider plays a critical role in both the safety of the procedure and the quality of the results. A trained professional ensures the treatment is done in a sterile environment with medical-grade equipment, reducing risks like infection and cross-contamination during blood handling and centrifuge processing [6]. They also tailor the needle depth – ranging from 0.5 mm to 2 mm – based on your specific needs, whether you’re targeting deep acne scars or fine lines.

There’s a clear distinction between professional and non-professional treatments. Studies show that professional expertise leads to noticeably better outcomes. For instance, FDA-cleared devices like the SkinPen create precise, controlled micro-channels, while at-home rollers can cause uneven tissue damage and increase infection risks [6].

“Professional treatment is crucial for both safety and results” – Scott Melamed, President and CEO of ProMD Health [6]

What to Look for in a Provider

When choosing a provider, prioritize board-certified professionals with extensive experience in microneedling with PRP. Look for certifications in dermatology or plastic surgery from respected organizations like the American Academy of Dermatology [1]. This is particularly important since the procedure involves handling blood and using specialized equipment.

Ask to see before-and-after photos of past clients and confirm that FDA-cleared devices are used [6]. During your consultation, share your medical history – especially if you’ve had issues like cold sores or keloid scarring – and ask about the provider’s experience with this procedure. Providers who perform the treatment frequently tend to achieve better results [1].

By focusing on these factors, you can find a trusted expert to guide your aesthetic journey.

Calista Aesthetics: A Trusted Partner

Calista Aesthetics offers microneedling with PRP using FDA-cleared devices like the SkinPen, ensuring precise and safe treatments in a sterile environment [6]. Their team is committed to personalized care, tailoring treatments to your unique skin concerns – whether it’s acne scars, fine lines, or uneven texture. With an emphasis on expert care and natural-looking results, Calista Aesthetics stands out as a reliable choice for your skincare goals.

Conclusion

Microneedling with PRP taps into your skin’s natural ability to heal itself. By creating controlled micro-injuries and combining them with your body’s own growth factors, this treatment helps improve skin texture, tone, and firmness. It’s also effective for reducing acne scars, fine lines, hyperpigmentation, and enlarged pores. Clinical studies back its effectiveness, and because it uses your body’s own resources, it’s a safe option for all skin types.

“What could be better than harnessing the amazing healing powers of our own body to improve our skin?” – Cynthia Diehl M.D, F.A.C.S. [4]

Most patients undergo 3–6 sessions spaced four weeks apart, with noticeable changes typically appearing within 4 to 6 weeks [7]. The cost of a full treatment plan ranges from $2,250 to $4,500, with individual sessions averaging about $750 [2]. This makes it a gradual, natural approach to skin rejuvenation.

The success of your treatment hinges on expert care. Choosing a board-certified provider who uses FDA-cleared devices and adheres to strict safety standards is essential. At Calista Aesthetics, microneedling with PRP is performed using the SkinPen in a sterile environment, with customized plans designed to address your specific skin concerns. Reach out to Calista Aesthetics today to begin your journey toward healthier, revitalized skin.

FAQs

Microneedling combined with PRP (platelet-rich plasma) takes skin rejuvenation to the next level by introducing concentrated growth factors directly into the microchannels created during the procedure. These growth factors work to speed up the healing process while stimulating the production of collagen and elastin – two key components for firm, youthful skin.

This dynamic duo enhances results, improving skin texture, evening out tone, and restoring a natural glow. By integrating PRP with microneedling, you’re equipping your skin with the resources it needs to renew and repair itself more efficiently, leaving it smoother and healthier in appearance.

When it comes to microneedling with PRP, prioritizing safety is essential for achieving the best outcomes while keeping risks to a minimum. A key factor is sterility – the procedure should always use sterile, single-use needles in a clean, controlled environment to lower the risk of infection. Additionally, the PRP (platelet-rich plasma) must be prepared with care to ensure it remains uncontaminated and effective.

It’s also crucial to determine if this treatment is right for you. People with active skin infections, certain skin conditions, or blood clotting disorders may not be suitable candidates. Before starting, you might need to avoid things like sun exposure, blood thinners, or certain skincare products to reduce potential complications.

After the procedure, proper post-care is just as important. Using sun protection and sticking to gentle skincare routines can aid in healing and help you get the most out of the treatment. Following these steps ensures a safer experience and maximizes results.

You might start seeing some changes in your skin roughly a week after undergoing microneedling with PRP. That said, the real transformation happens over the next several weeks and months. During this time, your body ramps up collagen production, which can result in skin that feels smoother, looks firmer, and has a healthy glow. Remember, though, that results can differ from person to person based on factors like skin type and individual treatment goals.